Unchained Labs Uncle Protein Stability Analyzer, Made in 2024 Unit 3

Internal part number 65051

For Sale Unchained Labs Uncle Protein Stability Analyzer Unit 3

• Fully Functional
• Serviced & in Stock
• Current Model
• Made in 2024
• Good cosmetic condition
• Technical sales consultation available
• 60 DAYS INTERNATIONAL WARRANTY
• Includes remote instrument setup and training session 

Here is what you will receive:

• Unchained Labs Uncle Protein Stability Analyzer
• Standard power cord

Uncle Protein Stability Analyzer Configuration:

Techniques: Full-spectrum Fluorescence, Static Light Scattering (SLS), Dynamic Light Scattering (DLS)

Sample Requirements:

• Minimum sample volume: 9 uL (sealed capillaries)
• Simultaneous samples per run: 48
• Sample concentration range: 0.05–300 mg/mL (IgG, protein dependent)

Temperature Control:

• Range: 15–95 DegC
• Accuracy: ±0.1 DegC
• Heating rate: 0.1–10 DegC/minute

Fluorescence and static light scattering:

• Sample precision: <2% CV (Tm)
• SLS resolution: ~15 kDa change in mean molecular mass
• AAV genome concentration: ≥5 x 1011 viral genomes per mL
• Excitation: 266 nm and 473 nm lasers
• Detection Fluorescence: CCD spectrometer at full 250–720 nm spectral range
• SLS: intensity at 266 nm and 473 nm

Dynamic light scattering:

• Hydrodynamic diameter range: 0.3–1000 nm
• Size accuracy: ±2%
• Minimum sample concentration: 0.1 mg/mL — lysozyme
• AAV capsid concentration: ≥5 x 1011 viral genomes per mL
• Molecular weight range: 192 Da – 25 MDa
• Light source: 660 nm laser diode
• Detection: avalanche photodiode module

Customization/Options: N/A

Testing performed by our in-house service team: 

• We power on the system and confirm successful initialization.
• We clean and inspect the unit for any signs of wear or damage.
• We test and verify the connection to the control software.
• We prepare a protein sample and load it into a “Uni” for testing runs.
• We test Thermal melting (Tm) during the run.
• We test Thermal aggregation (Tagg) during the run.
• We test Sizing and Polydispersity using DLS capability.

Instrument Overview:

• Uncle combines fluorescence, SLS, and DLS to analyze stability with minimal sample volume.
• Measures Tm, Tagg, size, polydispersity, and viscosity using 9 uL samples in sealed capillaries.
• Supports 48 samples per run with temperature control from 15–95 DegC and heating rates up to 10 DegC/min
• Features excitation at 266 and 473 nm with full-spectrum fluorescence detection from 250–720 nm
• The Unchained Labs Uncle detects aggregation and hydrodynamic diameter from 0.3 to 1000 nm.
• Compact and efficient, the Uncle Protein Stability Analyzer offers high-throughput biophysical profiling.

Instrument Application:

• Tm & Tagg
• Tm with SYPRO (DSF)
• Isothermal stability studies
• Sizing & polydispersity
• Sizing with thermal ramp
• Viscosity, kD, B22, G22, ΔG
• Thermal recovery

The Key Features:

• Measures Tm, Tagg, and particle sizing
• Uses only 9 uL per sample
• Combines 3 technologies in one unit
• Supports high-throughput screening
• Works with proteins, biologics, and more
• Fast analysis with intuitive software

Our Advantage

• We have experience servicing and repairing these instruments.
• This instrument goes through all the described service steps before shipping.  see the questions section below  
• We offer detailed photos and videos of the instruments you buy.
• We are an approved pre-owned equipment vendor to many large US, Canadian, and EU Universities.
• We are an approved pre-owned equipment vendor to many Fortune 500 US and International Biopharma companies. 
• Technical sales consultation available
• Remote installation and instrument operation training may be available.
• On-site installation may be available in the Boston Area (New England area)
• US or International shipping is no problem (see the shipping tab on how we pack and feel at ease)

Our Guarantee

• Warranty
• An extended warranty may be available
• You get after-sales technical support
• Customer references are available
• The instrument will be fully functional!
• Smooth process from the initial quote to order fulfillment

This will ship via freight. Please contact us with your zip code to obtain a shipping quote.

PLEASE NOTE THAT THE QUESTIONS BELOW ARE ANSWERED IN MORE THOROUGH DETAIL ON OUR WEBSITE

Q: Can I view this instrument in person at your facility or do a live Zoom demo before it is shipped to me?
A: We can accommodate both in-person or Zoom demos.

Q: What about the warranty?
A: The instrument comes fully warranted for both parts and labor.

Q: Do you offer installation, service, etc?
A: We offer remote installation and training packages to familiarize you with this instrument.

Q: What should I watch out for when buying a used/pre-owned instrument from another lab?
A: Ensure that the instrument is in good working condition with no damage or wear that could affect its performance. Ask for details about testing steps performed, video demo, and test screenshots.

Q: Do you have more than one of these instruments on hand?
A: We generally carry multiple instruments on hand, along with a variety of spare parts.

Q: This procurement is for a University or College. Are purchase orders with NET terms accepted?
A: We accept purchase orders from all major US and Canadian universities.

Q: How fast will you ship?
A: We can ship within a few days to two weeks. Shipping time depends on the current demand for our instruments. Members of our sales team will be able to offer current delivery estimates.

Q: Will my instrument be insured during shipping?
A: Absolutely! We insure all our shipments as long as we are the shipper.  If a customer ships on their account, they handle insurance.

Q: How do you pack? Have you previously packed and shipped the fragile laboratory instruments?
A: We have extensive experience shipping high-end and complex laboratory instruments in the US and Internationally.  

Q: Do you ship Internationally?
A: Yes! We have shipped to multiple continents and over 30 countries. 

Q: How much will I save buying it pre-owned, and is it worth it?
A: When compared to buying a new instrument, you will save 60% or more and have plenty of funds left over for an additional instrument or two.